Labskin – Understanding how it works
Advanced skin model
Our highly advanced 3D living skin equivalent model (Labskin) is unique in providing unrivalled opportunities for non-animal testing and research. The fully differentiated epidermis is supported by a dermal component consisting of fibroblasts in a fibrin matrix. The model also allows microorganisms to be grown on its surface, mimicking infection or the skin’s natural microflora. This configuration ensures we can assess your skin care ingredients and formulations with possibly the most comprehensive range of tests available in an in vitro model. Available assays include assessments for antimicrobial and pre-biotic activity, penetration, anti-ageing and anti-inflammatory properties.
Living skin equivalents
Understanding how a new product ingredient or formulation will perform on skin (and its associated microflora) is crucial to the development or advancement of skin care products.
Our unique living skin equivalent model, Labskin allows you to evaluate your product and provides good clinical evidence of its effectiveness before you fully commit to clinical studies.
We are continually developing Labskin as a technology, to broaden the applications for which it can be used.
Labskin is a living skin equivalent, capable of modelling the skin’s likely reaction to innovative cosmetic and pharmaceutical technologies. The development of Labskin is the result of over 10 years of world class research.
Labskin Tech Specs
|Surface Area||1.1 cm2||4.5 cm2|
|Skin thickness at casting||5-6 mm|
|Culture insert diameter||1.2 cm||2.4 cm|
|Permeable membrane pore size||3.0 µm|
|Permeable membrane pore density||2 x 106 cm-2|
|Medium||Enough for up to 14 days culture|
|Culture plates||1 deep well culture plate supplied, more available upon request.|
|Keratinocytes||Normal human neonatal epidermal keratinocytes – pooled|
|Fibroblasts||Normal human dermal fibroblasts – single donor|
|Biohazards||HIV, Hepatitis B and C negative|
|Base||Proprietary modified Green’s medium|
|Transport medium||Medium gel solidified with agarose|
|Shipping days||Day 7 or 12 of culture at air liquid interface.|
|Histology||Paraffin embedded and H&E stained at day 7 and 12 ALI
5+ vital and cornified layers expected.
|Visual inspection||Entire batch inspected for macroscopic morphology.|