Skin Science

Research Blog

26/04/18 Attendance to Wounds UK Infection Day and 5th SIG Mass Spectrometry Imaging Symposium

The week commencing the 16th April, Innovenn was lucky enough to present at the 5th SIG Mass Spectrometry Imaging (MSI) Symposium at Sheffield Hallam University and attend the Wounds UK Infection Day at York Racecourse.

The MSI Symposium gave a fantastic overview of the latest research being conducted across the world in both academia and industry. There were subtle differences in the use of MSI in research between industry and academia. There was definitely an emphasis on MSI as part of a complimentary analysis technique in a multimodal approach to discover a drug’s mode of action whereas, academia is advancing the technique to get the best spatial resolution and optimising deposition and ionisation strategies to detect a wider range of analytes. The diversity in the information gained from using this technique was highlighted in all the talks and posters presented at this thought provoking conference. We would also like to congratulate Cristina Russo from Sheffield Hallam University for winning best poster, especially as her PhD is using Labskin to assess the quantitation limits of MALDI-MSI.

We attended the Wounds UK Infection Day as delegates and we were extremely fascinated to hear about all the research going on at hospitals to help alleviate wound infections. There were a lot of discussions on the antibiotic resistance crisis and implementing new strategies to prevent surgery site infections by improving the perioperative care (thorough skin preparation prior to surgery and antibiotic administration immediately after surgery). There was a definite key message to take home highlighting wounds are dynamic environments and preventative is better than cure.

Here at Innovenn, we love being involved in current research and listening to all the novel work being conducted around the world.

20/04/18 Potential applications of Labskin

Our product, Labskin, is extremely versatile and can be used for a number of different applications. We are fortunate enough to be able to conduct research in-house as well as collaborating externally with research partners. The number of publications in peer review journals using Labskin, highlight the diversity and adaptability of Labskin in a variety of applications in which Labskin may be used for in research. In-house service facilities and external projects have used Labskin to test the potency of product ingredients and formations as well as drug penetration efficacy. However, recently there has been particular interest in understanding the interactions between the product and cultured microflora on Labskin. These more complex models provide a better representation of human skin through mimicking natural skin microflora or opportunistic pathogenic strains in a controlled environment. Therefore, providing more realistic in vitro alternatives to animal testing.

Our external collaborations have used Labskin to assess the product’s responses along side in depth cellular responses. These responses have been explored either directly through genomic and proteomic analysis or in-directly through secretion analysis. Enzymatic activity in Labskin have been assessed after the application of specific drug compounds, which was then compared against ex vivo human skin to create a xenobiotic metabolism database. Additionally, Labskin as been used as a platform for wound healing biomarker discovery, which may be used to help identify whether a wound is starting to heal or develop into an infected/chronic wound.

The diversity and versatility of the use of Labskin provides an excellent in vitro platform to explore human skin responses within a laboratory setting.

13/04/18 In-house R&D programme

As a company, we are extremely fortunate to have multi-disciplinary research amenities where we are able to combine cell culture and microbiology facilities next to each other. This allows us to conduct numerous in-house research and development programmes to test Labskin’s capabilities within a novel environment. Recently, we have been particularly focused on creating models with different microflora on Labskin to create more realistic in vitro skin models. Projects have included creating models, which mimic human in vivo pathogenic fungal colonisations (Dermatophytes) on the skin or human native bacteria. At the minute, there is a global interest in the benefits of applying prebiotics to aid growth or activity of beneficial microorganisms on the skin to recalibrate the skin to a create healthy microbiome. We have been involved in some fascinating projects where we are simulating the effects of different prebiotics on Labskin inoculated with various strains of bacteria.

Over the last couple of years, we have also developed a model to replicate the initial wound healing response and create an infected model, which simulates the processes found in vivo. From this project we were able to identify wound healing markers, which help identify whether a wound is healing in a clinical setting. We are extremely pleased with these results and these have been recently accepted in the International Journal of Cosmetic Science. Following the success of the project, the model is being developed further to create a wound consisting of biofilms to replicate chronic wounds.

We are proud of all the in-house projects we have undertaken and looking forward to unravelling all the capabilities Labskin has to offer and creating new and varied models.

05/04/18 External Collaborations

Labskin is currently being incorporated into some fantastic projects in research institutes around the UK. Following previous successful projects using Labskin at Sheffield Hallam University, we continue with our collaboration with Professor Malcolm Clench. There are currently three PhD projects, which all use Labskin to assess drug penetration, drug metabolism and cancer development. The drug penetration project is coming to an end and has generated novel results quantitatively assessing fungicide penetration through the epidermis using different product formulations. This work is currently being written up to be published in the very near future and we are extremely excited with the results. We will keep you updated with all the developments of the paper once it has been accepted and published.

Since last year, we have been working with Dr Raechelle D’Sa from the University of Liverpool on a project using Labskin to test innovative antimicrobial bandages for the treatment of wound infections. The project wants to assess the efficacy of bandages containing nitric oxide releasing nanoparticles on wounded and infected Labskin. This project is still in its infancy and preliminary work is still being conducted but we are extremely happy to be involved with this.

As a company, we are thrilled about all the projects being undertaken at the minute with Labskin and cannot wait for all the new results being generated.

 

 

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